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Description Paroxetine is used to treat depression, obsessive-compulsive disorder (OCD), panic disorder, generalized anxiety disorder (GAD), social anxiety disorder (also known as social phobia), premenstrual dysphoric disorder (PMDD), and posttraumatic stress disorder (PTSD). Brisdelle® is used only to treat moderate to severe hot flashes caused by menopause. Paroxetine belongs to a group of … The concomitant use of PAXIL with another drug that is highly bound to plasma protein may increase free concentrations of PAXIL or other tightly-bound drugs in plasma. Paroxetine is used to treat depression, obsessive-compulsive disorder, anxiety disorders, PTSD, and premenstrual dysphoric disorder. Learn about side effects, dose indications, interactions, and more. 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