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Best allergy drops for concurrent sinus and systemic allergy issues BEPREVE® (bepotastine besilate ophthalmic solution 1.5%) Mechanism of Action: direct H1-receptor antagonist, an inhibitor of the release of histamine from mast cells. Bepreve is a highly selective, H1 receptor antagonist which is to be dosed twice per day. Learn about how Bepreve's active ingredient, bepotastine besilate, helps soothe itching and redness caused by eye allergies. Find dosage, usage, and precautions information to use Bepreve safely and effectively. Buy Bepreve online and save up to 80% on costs. No US insurance needed. Compare prices from a certified Canadian pharmacy with fast shipping. Order now. Best Buy offers convenient payment options for purchases online and in our stores. bepotastine Bepotastine belongs to the class of medications called antihistamines, specifically the class known as histamine receptor antagonists. 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